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Phentermine increases heart rate and blood pressure through sympathomimetic activity, while GLP-1 agonists have shown mixed cardiovascular effectsbenefits in diabetic populations but potential concerns in certain patient subgroups, particularly those with a history of thyroid cancer or multiple endocrine neoplasia

The combination of GLP-1 and GIP activation is what makes tirzepatide produce faster and more significant results than single-target GLP-1 medications