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In REDEFINE 1 , a 68-week, Phase 3a, multicenter, double-blind, placebo- and active-controlled trial, 3,417 adults with overweight or obesity but without diabetes were randomized to CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg), semaglutide 2.4 mg, cagrilintide 2.4 mg, or placebo

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Statistical analysis A summary of the number of samples used for the different experiments in these studies is shown in Supplemental Table 3

1 Introduction Despite its prevalence, affecting nearly 10% of women (Al-Ghadban et al., 2019a), lipedema remains one of the most underdiagnosed and misunderstood connective tissue disorders, often being mistaken for obesity and lymphedema