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U.AteeqM.KUsmanMSajidS.et al
demonstrated that PF activates the JNK/Nrf2/HO-1 signaling pathway and interacts with the PDLIM1/RhoA/ROCK1 pathway to protect SOD (PIG1, PIG3V) from oxidative damage
This may help reduce oxidative stress and support healthier skin cells
GNE inhibition results in hyposialylation of IGF-1R Since the key function of GNE is epimerization and phosphorylation of precursors in the sialic acid biosynthetic pathway, absence of functional GNE would cause hyposialylation and affect sialylation of cell surface receptors 15,30
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