changing from tirzepatide to semaglutide What Happens When You Switch Ozempic? Tirzepatide as Compared with Semaglutide

Neuropsychopharmacology 42: 1471-1479, 2017

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Absolute contraindications: Personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN2), known hypersensitivity to semaglutide or any excipient Relative contraindications: History of pancreatitis, severe gastrointestinal disease (gastroparesis, inflammatory bowel disease), current pregnancy or planned pregnancy within 2 months, history of suicidal ideation or major depressive disorder (monitor closely) Use with caution: Patients on insulin or sulfonylureas (hypoglycemia risk), patients with diabetic retinopathy (risk of transient worsening), patients with renal impairment (adjust monitoring) Pre-Treatment Workup Thorough semaglutide training for physicians includes a standardized pre-treatment assessment protocol

6 CKD is a long-term condition that progresses slowly over time 7