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Additionally, its instability under physiological conditions and dose-dependent cytotoxicity at high concentrations further restrict its utility

In an RTT mouse model, it was found that AAV9-mediated intracranial delivery of the MECP2 transgene effectively increased survival and some behavioral phenotypes [43]

POF, Premature Ovarian Failure

3.3 Regulatory Pathways Glutamine metabolism and transport are tightly regulated by a combination of hormonal, nutrient sensing, and metabolic signals