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POI, formerly known as premature ovarian failure, is characterized by menstrual cycle disruptions and the loss of ovarian function before the age of 40

A randomized, double-blind, placebo-controlled in 129 young healthy adults found that taking a supplement that contained ten times the daily intake recommendations for nine different vitamins (vitamin A, thiamin, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , vitamin C, vitamin E) for one year improved one self-assessment of mood, i.e., being more agreeable (137)