Both drugs can cause weight loss through different mechanismstopiramate affects neuronal signalling, whilst semaglutide regulates appetite via hormonal pathways
in the latter, proopiomelanocortin (POMC) neurons are present and it is believed that endogenous GLP-1 induces satiety, affecting both anorexigenic and orexigenic signaling pathways
Before starting, stopping, or exploring any therapy or treatment, patients should consult their healthcare providers to determine the approach that best aligns with their individual medical needs and circumstances
Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al