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BPC-157 is a pentadecapeptide derived from the stomach that operates via an intricate network of cytoprotection and angiogenesis mechanisms, including VEGFR2, NO-eNOS signaling, FAK-paxillin interaction and others, with its most solid data being derived from gastrointestinal, tendon, ligament, bone, and increasingly neural studies

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However, it was Sipples description in 1961 that provided the first compilation of the association between thyroid cancer and pheochromocytoma (now known as MEN2A) (2,80)

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