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In addition, other endosomal TLRs, including TLR7-9, can upregulate IFN-I gene expression via IRF7 under certain conditions (38) ( Figure 4 )

However, in some interventional studies, copper has been shown to exert a protective effect on diabetic patients, and a restricted copper diet can also induce steatosis in the liver [261,262,263]

In ALS, the astrocytes are activated to release pro-inflammatory cytokines and chemokines, causing sustained neurotoxic effects and neuronal apoptosis (Bede et al., 2021), as illustrated in Figure 1