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Compared with tirzepatide, semaglutide 2.4 mg showed a significant 57% greater risk reduction for heart attack, stroke and cardiovascular-related death or death from any cause, in people with overweight or obesity and CVD, who did not have any gaps in their treatment lasting more than 30 days

Acute peripheral proteomic effects After 7 h of single subcutaneous administration, GLP-1GIPLani induced robust proteomic changes in the pancreas, with only minor effects in the eWAT, liver and skeletal muscle