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Certainty of evidence All primary and secondary outcomes were judged to have high certainty of evidence across all GRADE approach [11] domains, including risk of bias (D1), inconsistency (D2), indirectness (D3), imprecision (D4), publication bias (D5)

FDA approval is expected by 2027

In vitro analysis of human erythroid progenitor cells that underwent shRNA knockdown of HDAC1 or HDAC2 genes resulted in increased levels of -globin but without altering cellular proliferation of the cell cycle phase