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Black or tarry stools may be due to bleeding in the upper part of the GI (gastrointestinal) tract, such as the esophagus, stomach, or the first part of the small intestine

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267 Claudin-7 (Cldn-7), a member of the tight junction protein family, is closely related to inflammation and tumor development, and Cldn-7 deficiency can significantly upregulate the expression of -catenin and its downstream target genes c-myc and cyclin D1 by promoting aberrant activation of the Wnt/-catenin pathway, which in turn leads to abnormal cell proliferation and tumorigenesis

From now on, you'll always clean that hub with an alcohol swab before drawing up your dose