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NG497 is the first human-specific ATGL small-molecule inhibitor that targets the patatin-like domain of human ATGL enzyme activity, eliminating the hormone-stimulated FA release in adipocytes (130)
Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice
The attachment of an acetyl group protects glutathione from oxidation in the digestive tract, rendering it more stable
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