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Second, further research often reveals an involvement of the system under study in other processes and organs, which is crucial for translational medicine and confirms the fundamental premise of integrative physiology and neurobiology regarding the intricate relationship between various body organs

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X-ray structural analysis and biochemical studies found that the increased activity of superPLDs (up to 100-fold higher than the parental PLD when expressed heterologously in mammalian cells) resulted from a combination of several mutations around the periphery of the enzyme rather than any key residue in the active site

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