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Rationale for combination therapy and comparative overview SGLT2 inhibitors and GLP-1 receptor agonists provide cardiovascular benefit through distinct clinical profiles

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In a pre-specified blinded extension for those with a BMI 35, participants who continued on retatrutide 12 mg to 104 weeks lost an average of 85.0 lbs (30.3%).2 Additionally, retatrutide showed significant improvements from baseline across certain cardiovascular risk factors, including waist circumference, non-HDL cholesterol, triglycerides, systolic blood pressure and high-sensitivity C-reactive protein (hsCRP)