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The mice also showed increased mitochondrial protein expression in white adipose tissue, suggesting a shift toward a more metabolically active phenotype

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Karger Publishers.

Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585