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The interaction between the gut microbes and their metabolites is suggested to introduce a fourth facet of communication to the gut-brain axis [146]

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The ZIP transporters, which are membrane proteins, facilitate zinc uptake into the cytosol either from the extracellular medium (Zhao and Eide, 1996) or from intracellular compartments like the vacuole and endoplasmic reticulum (MacDiarmid et al., 2000)