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MRI-based studies from the SURPASS-3 program and related tirzepatide trials show that tirzepatide produces large reductions in visceral and liver fat while preserving a higher percentage of lean muscle

Clinical studies have shown patients losing an average of 15-20% of their body weight with Semaglutide treatment

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Apart from the chronotropic effects, direct effects of GLP-1 specifically on the heart have not been comprehensively documented, although evidence exists to suggest that GLP-1 RAs may improve cardiac output as well as cardiomyocyte survival (Ravassa et al., 2012