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15 Additionally, by supporting better blood pressure control and vascular function, GLP-1 RAs may offer protection against hypertensive retinopathy and retinal vascular occlusions such as central or branch retinal artery or vein occlusions

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"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here