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Early-stage human data is interesting but limited

It had been shown that protein kinase R (PKR) was activated in the later stages of HSV-1 infection enhancing phosphorylation of eIF-2 (Chou et al., 1995) and inducing phosphorylation of endoplasmic reticulum resident kinase (pERK) (Cheng et al., 2005), thereby inhibiting protein synthesis (Poppers et al., 2000)

Therefore, these factors should be taken into consideration and regular monitoring should be performed in these conditions while treating vitamin B12 deficiency with cyanocobalamin

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