( Unfortunately, this symptom of B12 deficiency overlaps with symptoms related to diabetic neuropathy nerve damage caused by high blood sugar that can cause pain and numbness in the extremities ( People with diabetes taking metformin are at a higher risk of developing B12 deficiency because this medication can reduce vitamin B12 absorption in the body ( So, a B12 deficiency could be misdiagnosed as peripheral neuropathy in people with diabetes
Preclinical evidence supports the role of GLP-1RAs in alleviating neuropathic pain through the modulation of microglial activity, inflammatory cytokine production and -endorphin release [63, 65, 68, 70,71,72,73,74]
Number of Sessions Needed: On average, individuals may need between 8 to 10 sessions to observe visible results, though some people may require more depending on their original skin tone and pigmentation level
The combination of these two medications offers a comprehensive approach to managing the dual challenges of hyperglycaemia and excess weight, addressing multiple pathophysiological mechanisms simultaneously