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Some patients report stronger appetite reduction when they inject in the evening, possibly because the medication peaks during sleep and early morning hours when hunger typically increases

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Weekly injection patients in major trials showed better weight loss and adherence when they maintained a fixed schedule rather than attempting compensatory dosing

Nathanson D, Ullman B, Lfstrm U, Hedman A, Frick M, Sjholm A, Nystrm T: Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety