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The consequences of heterodimerization with GHS-R1a can lead to altered signaling such as is the case for the D1R

The addition of the DAC affinity complex allows the peptide to bind covalently to albumin, a highly abundant blood protein

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Proteins Casein protein [129], whey proteins [130], peptones [131], and different amino acids such as l-glutamine [132], l-phenylalanine [133], L-tryptophan [134], and l-arginine induce GLP-1 secretion through activation of the calcium-sensing receptor (CaSR), the taste receptor TAS1R1/TAS1R3, G-protein-coupled receptor 6A (GPRC6A) [135], GPR142, peptide transporter-1 (PEPT1) [136], and amino acid (AA) transporter [137] (Fig