Such diversity is highly unusual among Eukaryotes: a canonical arrangement has been conserved in GS enzymes for ~1 billion years of evolution in three kingdoms of life (Fig 5, Plantae (St-GSS1-closed, PDB 5OES), Fungi ( Saccharomyces cerevisiae , PDB 1M0T), and Animalia ( Homo sapiens GSS1, PDB 2HGS))
Cohen LH, Vamos E, Heinrichs C, Toppet M, Courtens W, Kumps A, Mardens Y, Carlsson B, Grillner L, Larsson A: Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency
To illustrate the potential of these models, several examples from recent simulation studies are presented, including equilibrium and non-equilibrium membrane structures, membrane remodeling, and deformation in fluid flow
still, many meat eaters today are also surprisingly deficient