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For people who are used to regularly drinking coffee, some some research suggests coffee may not be as dehydrating as its reputation suggests But drinking a lot of coffee 500 mg of caffeine or more can have a diuretic effect

This has important implications for how we identify individuals who may be more likely to develop psoriasis or experience more severe disease, and how we approach prevention and treatment strategies. Catherine H

thus, we included this effect in a scenario analysis

For participants whose samples were collected from both sources, we selected the protein sample that matched the source of transcriptomics (Extended Data Fig