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1: Family tree illustrating possible HAE inheritance.) Conclusion: This case highlights the clinical variability of HAE, particularly in newly described genetic variants

After full-text assessment, we excluded studies on diabetes mellitus ( n = 154), studies on Parkinson or neurodegenerative conditions ( n = 8), and in vitro, animal and human studies that did not investigate pain as primary and/or secondary outcome ( n = 130)

Davis Aging Brain Scholar and a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease, and is supported by a McKnight Brain Research Foundation Innovator Award in Cognitive Aging and Memory Loss, a Kenneth Rainin Foundation Innovator Award, an NIH Directors New Innovator Award (DP2-AG-067492), an NIDDK Catalyst Award (DP1-DK-140021), NIH R01-NS-134976, NIH R01-DK-129691, and the Human Frontier Science Program (HFSP)

10.1126/science.1206095 Science