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More serious complications may include swelling of the pancreas, gallbladder disease which sometimes requires surgical removal, loss of muscle tissue, kidney injuries and hypoglycaemia, especially when combined with other medications

The average weight loss on retatrutide in clinical trials has been up to 24% of body weight, which is significantly higher than other GLP-1 receptor agonists like semaglutide

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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]