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For each patient, the patient history can be traced back to the later of birth or 1983, and followed up to the end of the study or death of the patient, whichever came earlier

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Factors known to affect caking kinetics may be divided into intrinsic properties of the powder itself (water activity, particle size distribution, presence of impurities, and glass transition temperature) and external factors such as temperature, relative humidity and mechanical stress applied to the substance [13]

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