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High blood sugar and insulin resistance can negatively affect the gut lining and the balance of the microbiome

In addition, patients with previous Roux-en-Y gastric bypass, sleeve gastrectomy, gastric banding and other less common bariatric procedures were excluded

Targeting the Trem2-APOE pathway can restore the homeostatic signature of microglia in ALS and AD mouse models, potentially preventing neuronal loss and promote tolerogenic T-cell response (Krasemann et al., 2017)