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A common example is with vitamin D, and heres why: Vitamin D is fat soluble, so your body stores it Taking more than the recommended upper limit for long periods can lead to high vitamin D levels, and high calcine can lead to kidney and heart problems If you are on a higher dose of vitamin D for a specific medical reason or for longer than a short course, your provider may want to check your levels and other labs to stay on top of safety

This is by design: the long half-life allows once-weekly dosing, but the trade-off is that side effects don't reset between doses

No brain atrophy was evident until animals reached at least until 3 months of age for GCLC floxed X Iba1-Cre (Fig