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By binding to ER in endothelial cells, estrogens induce nitric oxide (NO) release, consequently producing vasodilation (Penotti et al., 1996), and the impedance of this flow appears to be reduced after starting hormone (estrogen) replacement therapy (HRT) ( Estrogens and Neurodegenerative Diseases Experimental and clinical data suggest that estrogens have protective effects against neurodegenerative diseases (Kumar et al., 2010

(VI) Autocrine Met-induced-activation is due to ectopic Met expression in cells yielding HGF, especially in acute myeloid leukemia (Zhang et al., 2019)

Melatonin synthesis is also described in many other sites

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