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There is no international criteria for the diagnosis of BRRS, but Marsh et al 49 defined at least three of the following four features: macrocephaly, lipomatosis, hemangiomas, and speckled penis in males, whereas Parisi 52 defined it as at least two of three features of macrocephaly, hamartomas (at least one lipoma, hemangioma, or intestinal polyp), and penile macules in males

But the science, strategy, and scale behind these therapies are far more complex than the public narrative suggests

Researchers might explore this combination in models of severe metabolic dysfunction where both NAD+ depletion and poor mitochondrial health are present