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Several garlic-derived organosulfur compounds, including S-allylcysteine and ajoene, have been found to inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), a critical enzyme in the cholesterol biosynthesis pathway (39, 40)
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The glucagon component directly stimulates thermogenesis in brown adipose tissue and drives hepatic fat oxidation, increasing resting energy expenditure through a mechanism that pure GLP-1 drugs cannot replicate
For patients with severe or persistent GI symptoms, temporary dose reduction or holding the GLP-1 medication (under clinician guidance) may be considered
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