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Starting from the observation that oxygenation improved in patients in the prone position, studies identified several physiological mechanisms underlying this improvement, including a decrease in the differential distribution of ventilation between the ventral and caudal lung regions and a shift in the density distribution of the edematous lung, increasing the V/Q ratio

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doi: 10.1038/jid.2015.223

Individual response still varies, which is why the biology you bring to the molecule matters as much as the molecule itself when a clinician considers a protocol