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SURMOUNT-1 subgroup data from 2,542 women showed tirzepatide produced ~23% body weight reduction in peri/postmenopausal women vs 3% on placebo

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Indeed, it is puzzling why only IGLE neurons detecting intestinal distention induce satiation, while mucosal ending VANs that contain gut peptide receptors and are ideally situated in close proximity to EECs would not be involved in metabolic homeostasis