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These findings are consistent with reduced myocardial stiffness and remodelling, but remain surrogates rather than direct measurements of fibrosis

Here is how the EPIC trial researchers originally stated the objective of their study: "Investigators will determine if chronic oral administration of pimobendan in dogs with evidence of increased heart size secondary to preclinical MMVD can delay the onset of signs of CH F

doi:10.1038/s41574-019-0275-6 Williams JA

For what is anticipated to be a limited set of customers whose clinical needs cannot be met using the increasingly varied set of commercially available FDA-approved GLP-1s, Hims & Hers plans to offer access to compounded GLP-1s if a provider determines that a compounded product is clinically necessary