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To assess whether GGCT metabolic enzymatic activity regulates changes in the TCA cycle, we predicted the structure of GGCT and constructed a mutant (E98A) in PC3 and DU145 cell lines [20] (Fig

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During sepsis, systemic inflammatory responses, dysregulated immune responses, hepatic microcirculatory dysfunction and cellular hypoxia can lead to various forms of acute liver dysfunction, including hypoxic hepatitis, sepsis-associated cholestasis or acute liver failure (118)

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