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5 A, B, and Supplementary Fig

Understanding how B12 shots work sets the stage for comparing them with IV infusions

In murine hypertrophic hearts models, the upregulated expression of mitochondrial protein sideroflexin 1 (SFXN1)mediates mitochondrial iron overload by transferring iron from the cytoplasm into the mitochondria, leading to excessive mitochondrial ROS production and increased lipid peroxidation, which triggers ferroptosis [232]