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They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses

Mistake 4: inadequate hydration GLP-1 receptor agonists can blunt thirst signals while simultaneously causing fluid loss through GI effects

The sensation typically peaks within 30-60 seconds and diminishes as local pH normalizes

Avoid smoking and excessive alcohol consumption