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The correlation between hub immune cells and mitochondrial metabolic pathways was examined using the Mantel test and Pearson correlation coefficients in the pSS group and visualized using the ggcor R package (version 0.9.8.1) ( based on ggplot2 package

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Retatrutide is a synthetic multi-agonist peptide engineered to target three metabolic hormone pathways at once: GLP-1 receptor for appetite suppression and glucose-dependent insulin secretion GIP receptor for improved insulin sensitivity and lipid metabolism Glucagon receptor for increased energy expenditure and lipolysis This triple mechanism provides more comprehensive metabolic effects than dual agonists like tirzepatide, making Retatrutide a leading compound in current incretin and obesity research

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