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Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results

A study of 200 adults found that participants who combined adequate protein intake with resistance training lost 13% of their body weight but only 3% of their muscle mass

8 Limitations This review has several limitations that warrant consideration

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