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In general, three different groups of agents were described in the past: (i) mAbs, either targeting the ligand HGF or the receptor Met, (ii) tyrosine kinase inhibitors, targeting the tyrosine kinase domain of Met (and mostly also the TK domain of other RTKs), (iii) a truncated, soluble Met receptor serving as decoy for HGF (44) and the competitive HGF antagonist NK4 (18)

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Five or more consecutive missed days during a loading phase may slow progress

Since then, the Geiers have opened eight clinics in six states, including one in Springfield and their arrangement with Eisenstein, which he described as a franchise of sorts