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In a Japanese cohort, HISCL plasma A42/40 showed a best cut-off around 0.094 and a transition near ~19.3 Centiloids, earlier than typical PET visual positivity around ~32.9 CL
This is a greatly simplified account of the process, and at least 25 proteins take part both in the transport and -oxidation aspects, some of which are organized into at least three functional subdomains, one associated with the outer mitochondrial membrane, one with the inner mitochondrial membrane and the other in the matrix
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