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Harmful effects of zinc excess Excess of zinc can have a series of harmful effects on animals, manifested mainly in its interference with the absorption and utilization of other minerals, its impact on enzyme activity, and the potential risk of promoting the emergence of antibiotic-resistant bacteria [150, 154]

Heerspink HJL, Karasik A, Thuresson M et al (2020) Kidney outcomes associated with use of SGLT2 inhibitors in real-world clinical practice (CVD-REAL 3): a multinational observational cohort study

In contrast, in another RCT in which ADF led to a significant reduction in energetic intake, and rapid weight loss, a reduction in lumbar spine BMD was reported (Reference Stekovic, Hofer and Tripolt57)