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The metabolic improvements from GLP-1 medications (weight loss, improved insulin sensitivity, reduced inflammation) combined with the cardiovascular benefits of estrogen replacement create a favorable risk profile
This precision-health approach is especially valuable for bariatric patients who've already invested in surgery and want to maximize the next phase of their weight loss journey
ERs are transcription factors that undergo conformational modifications, upon estrogen binding, that induce the receptor to interact with DNA elements within target gene promoters and transcriptional coregulators
It was a signal
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