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In other words, weight loss is an off-label (not FDA-approved) use of Ozempic, whereas it is an approved use of Wegovy

The FDA does not recommend using medications beyond their labeled expiration dates, as the manufacturer cannot guarantee full potency or stability after that point

Common adverse effects , particularly during dose escalation, include: Nausea (reported by 2050% of patients, usually mild to moderate) Vomiting, diarrhoea, or constipation Abdominal discomfort or bloating Reduced appetite (therapeutic effect, but may feel unusual initially) Fatigue or headache These effects typically diminish over several weeks as tolerance develops

Amylin alone also showed weight loss of 8.4% at day 36