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We did detect the monoisotopic mass of unlabeled mBBr-thiosulfate adduct in the assay with the wild-type enzyme, but we observed similar levels of unlabeled mBBr-thiosulfate adduct with the C408A variant, and in the absence of enzyme (control, Fig

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Nascimben L, Ingwall JS, Lorell BH, Pinz I, Schultz V, Tornheim K, Tian R (2004) Mechanisms for increased glycolysis in the hypertrophied rat heart

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The initial findings were so impressive that some researchers suggested BPC-157 could be the prototype of a new class of organoprotective agents. There were still many unanswered questions, though: Would other studies replicate these findings

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