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Se presenta una serie de 6 casos, incluyendo 2 pacientes de una misma familia, se revisa la literatura y se discute su diagnstico diferencial con otras enfermedades locales y sistmicas trascendentes que tambin muestran pigmentaciones maculares cutneas, en labios y mucosa bucal, haciendo nfasis en las caractersticas clnicas como clave para su diagnstico y tratamiento adecuado

The MichaelisMenten constant (KM value) was previously determined to establish the substrate concentration at which the reaction rate reaches half of the maximum velocity ( 2.8.3 Scanning electron microscopy (SEM) The analysis was performed using a Quorum Q150R ES (USA) device with a sputter voltage of 60 mA and a sputter time of 40 s

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