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Elevated serum GDF15 levels have been documented in chronic inflammatory and autoimmune conditions such as RA and SLE 15,16,17

Of note, the mean basal insulin dose at the study endpoint (week 52) was 48.8 U with insulin degludec in the SURPASS-3 trial and 43.5 U with insulin glargine in the SURPASS-4 trial [20, 21]