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2.2 Dysregulation of neurotrophic support Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), constitute a signaling axis fundamental to neuronal survival, differentiation, and synaptic plasticity within the central nervous system (Numakawa and Kajihara, 2025)

Tesamorelin does not hold a marketing authorisation in the United Kingdom and is not available via routine NHS prescribing or as a BNF-listed product

They form an oval under the skin around your mouth

Thats why responsible prescribing as Scott highlights requires screening for disordered eating, nutritional compromise, and vulnerability factors